Data from nonclinical and clinical studies in the clinics and laboratories in Japan, the USA, Russia, Ukraine, Georgia indicate the unique properties of plant peptides of the preparation GA-40 to react with the membranes of cancer cells and activate the mechanisms of their programmed death. In addition, the peptides of GA-40 attract additional reserves of the immune system to work on malignant cells, such as T-lymphocytes, phagocytes, and NK-cells.
It is obvious that in any patient with cancer, the immune system is exhausted and is working at the physiological limits. Under these circumstances, an administration of highly toxic antineoplastic agents with the purpose of stopping or delaying the disease progression may aggravate the patient’s condition due to the negative influence on the immune system.
To support the patient’s immune system and attract supplementary reserves of antitumor immunity, the introduction of a powerful immunocorrector is required, which is able to realize the protective potential of the body on a full scale. GA-40, a plant peptide-based preparation, copes with this task. GA-40 obtained from the whorled Solomon’s-seal mainly contains small peptides with a molecular weight of 15 to 98 kilodaltons. Such peptides, due to their ability to penetrate into the cells, have evolutionally formed properties to react with intracellular structures: regulatory proteins and genes, ligands and enzymes. GA-40 protects cells from virus entry, and also deprives the latter of the opportunity to replicate intracellularly. However, if the damaged cell is nonviable or shows signs of malignancy, GA-40 stimulates its apoptosis, i.e. programmed cell death. This process cleans the body’s tissues of dangerous cells and creates conditions for growth of normal ones.
Despite the emergence of modern anticancer drugs, it is almost impossible to improve the treatment efficacy without the human body’s support with exogenous peptides. This is due to the fact that chemotherapeutic agents, as a result of the use of which tumor growth stops or even develops tumor regression, are toxic themselves. Cytostatic agents negatively affect the immunity and weaken the much-needed immune surveillance of malignant cells. Exogenous peptides are designed to break this vicious circle.
To support the patient’s immune system and attract supplementary reserves of antitumor immunity, the introduction of a powerful immunocorrector is required, which is able to realize the protective potential of the body on a full scale. However, one should remember in the face of the depressed function of immune surveillance over a tumor, the body should not be given an additional burden in the form of a heterogeneous protein; this is especially true of animal-based preparations. Exogenous peptides obtained from animal tissues have a relatively high molecular weight and, therefore, have pronounced antigenic specificity, which can provoke strong inflammatory reactions and allergies.
Unlike peptide preparations derived from animal tissues, GA-40 has an unsurpassed safety profile. GA-40 does not contain high molecular weight polypeptides of pronounced antigenic specificity. This is vital in case of the patient’s compromised immune system and lack of supplementary reserves to neutralize possible allergic reactions and inflammatory processes.
It is also important to note that the plant peptides of GA-40, due to their ability to attach to the cancer cell debris and attract phagocytes to them, improve tolerance to chemotherapy. After receiving information from peptides about the presence of a significant number of cancer cell debris in the body, phagocytes activate and synthesize cytokines, which attracts even more immune cells to cancer cellular debris. Thus, GA-40 speeds up the process of detoxing the body after chemotherapy.
The frequently asked questions about GA-40 are presented in this section. Please contact us for close consultation.
How does GA-40 work?
GA-40 is a preparation based on plant peptides, the world’s first gene protector. GA-40 is derived from whorled Solomon’s-seal (Polygonatum verticillatum) and contains plant peptides of a molecular weight 15 to 98 kilodaltons. Under natural conditions, these peptides protect plants from damaging effects of infections, toxins, and ionizing radiation.
Entering the human body, the peptides of GA-40 are able to protect the membrane and intracellular structures of normal cells – receptors regulated proteins, ligands and genes – from pathogenic viruses, bacterial toxins, and wave effects.
But the main point is that plant peptides realize their inherent effects: react with cell membranes and interact with regulatory proteins. When the patient’s organism is weakened by chemotherapy or antibiotics, the peptides of GA-40, through the interaction with the membranes of lymphocytes and macrophages, enhance the activity of cellular immunity. GA-40 not only protects normal genes, but also contributes to the programmed death of malignant cells.
The GA-40 gene protector has not only antitumor, but also anti-infective properties: it protects cells from the affections of viruses, prevents the reproduction of pathogenic bacteria, strengthen influence on the body by antibacterial and antiviral drugs.
Also, studies in 2019 showed that GA-40 helps cleanse the body of harmful toxins, has a pronounced detoxifying effect, including after heavy metal poisoning.
Is GA-40 safe in severe immunodeficiency?
Yes, it is perfectly safe. GA-40 is a lyophilisate of plant peptides of small molecular weight, obtained from environmentally friendly plant raw material. Unlike animal-derived immunocorrectors, GA-40 has an unsurpassed safety profile because it does not contain large molecular weight polypeptides that can trigger allergic reactions and autoimmune inflammatory processes.
What is GA-40 prescribed for?
GA-40 is indicated for any diseases and conditions associated with disturbance of the full-fledged immune response of the human organism, including chronic infections and cancer.
Clinical data also indicate that the plant peptides contained in the GA-40 preparation can inhibit the penetration of viruses into healthy liver cells, as well as activate regulatory macrophages, which in turn synthesize anti-fibrotic enzymes. Thus, GA-40 is successfully used to treat hepatitis and cirrhosis.
What clinical trials have been conducted to study GA-40?
Our research team works closely with the leading clinics and Research & Development Institutes of Georgia, the United States of America, Germany and Japan, which allows to conduct the nonclinical and clinical trials in accordance with the international GLP and GCP programs. In particular, nonclinical and clinical trials of GA-40 have been successfully completed under the international GLP and GCP programs at the following investigation sites: Laboratory of Biologically Active Substances and Molecular Biomedicine at the Department of Plant Physiology and Biotechnology, Tbilisi State University and with direct involvement of the Biomedical Research & Development Center of the Ministry of Health of Georgia; Research & Development Facilities of Otsuka Pharmaceutical Co., Ltd., Japan; Tokushima Cell Technology Institute, Japan; Department of Pathology, University of Washington, USA.
How long has GA-40 been used?
Yes, the experience with GA-40 has been accumulated for more than 20 years. GA-40 has proved its efficacy in the combined treatment of melanoma, cervical cancer, breast cancer, leukemia and other cancers.
What is the efficiency of GA-40 for treatment of melanoma?
The GA-40 gene protector has confirmed its ability to program an atypical cell for natural death or apoptosis. Tumor tissue receives a double blow: on the one hand, peptides use additional resources of the immune system to fight against atypical cells; on the other hand, peptides independently integrate into cell metabolism, causing its apoptosis. This is confirmed by clinical experience.
What is apoptosis?
Apoptosis is a natural programmed cell death. The mechanisms of apoptosis are triggered when biochemical processes are disturbed in a cell or signs of mutation appear. The use of GA-40 in patients with aggressive malignant neoplasms significantly improves the results of protocol treatment regimens.
How does GA-40 work in case of hepatitis and liver fibrosis?
The plant peptides of GA-40 are capable of reacting with both membrane and intracellular structures of hepatocytes. Peptides protect hepatic cells from the harmful actions of pathogenic viruses, prevent the virus integration into the nucleus of the hepatocyte, and also, due to the intracellular blockade of the TGF trigger protein, prevent the transformation of hepatocytes into fibrous fiber-producing cells. Thus, GA-40 prevents the onset of hepatic fibrosis.
Does it make sense to use GA-40 for the prevention of recurrences and metastases?
Yes, the experience of GA-40 using indicates its high efficiency in preventing metastasis and recurrences. For example, the use of GA-40 in patients with aggressive malignant neoplasms significantly improves the results of protocol treatment regimens.
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